Bleeding after birth, also known as postpartum haemorrhage, is the most common reason why mothers die in childbirth worldwide. Although most healthy women can cope well with some bleeding at childbirth, others do not, and this can pose a serious risk to their health and even life. To reduce excessive bleeding at childbirth, the routine administration of a uterotonic drug called Oxytocin which contracts the uterus has become standard practice across the world.
In this study, researchers from the Cochrane Pregnancy and Childbirth Group have reviewed the data of the births of 88,000 women who took part in 140 randomised trials, with the aim of identifying which uterotonics (including oxytocin, as well as misoprostol, ergometrine, carbetocin or combinations of these) are most effective in preventing excessive bleeding after childbirth and have the least side-effects.
Cochrane - Review - Drugs - Bleeding - Childbirth
The Cochrane Review found that ergometrine plus oxytocin; misoprostol plus oxytocin; and carbetocin on its own, were more effective drugs for reducing excessive bleeding at childbirth rather than the current standard use of oxytocin on its own.
The team analysed all the available evidence to compare all of the drugs and calculated a ranking among them, providing robust effectiveness and side-effect profiles for each drug. Side-effects can include vomiting, high blood pressure and fever.
University - Birmingham - Clinician - Scientist - Dr
University of Birmingham Clinician Scientist Dr Ioannis Gallos, of the Cochrane Pregnancy and Childbirth Group and Review Author, said: "Whilst death from postpartum haemorrhage is a...
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