Label-free optical measurements have become popular thanks to their ability to observe samples non-invasively. Techniques such as quantitative phase microscopy or Raman spectroscopy, as used in this study, have been extensively used in recent years to characterize specimens and identify cells from different origins. However, the specificity of these approaches usually only allows for the discrimination of cell types. The group shows in this study that fine processes such as macrophage activation within populations of identical cells is also possible.
Standard analysis methods are often destructive to the sample, or rely on contrast agents to detect specific molecules of interest, which limits the study to known target molecules. The approach developed here is based on non-invasive techniques that rely on the...
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