While examining human brain tissues, researchers from the University of Alberta and McGill University unexpectedly found that the tissues from people who had MS contained an extremely high level of a protein named calnexin, compared with those who hadn't had MS.
The researchers then tested the susceptibility of mice lacking calnexin to the mouse model of human MS (experimental autoimmune encephalomyelitis), and were astonished to find that the mice lacking the protein were completely resistant to the disease.
Causes - MS - Symptoms - Impairment - Dizziness
The causes of MS are not well understood. Symptoms vary widely but often include cognitive impairment, dizziness, tremors and fatigue. These problems are caused by a type of white blood cells called T cells that, after becoming activated, find their way into the brain and attack the protective covering -- myelin -- of neurons in the brain and spinal cord, causing inflammation and damage to the central nervous system.
"It turns out that calnexin is somehow involved in controlling the function of the blood-brain barrier," said Marek Michalak, a distinguished...
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