Black patients more likely to be excluded from prostate cancer trials - despite having a MUCH higher risk of the disease

Mail Online | 2/9/2018 | Jaleesa Baulkman For
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Black men have a higher risk of developing prostate cancer, but they are often excluded from clinical trials for the disease, new research claims.

Researchers found many African American men are shut out of these experiments because they have slightly low levels of neutrophils, a common type of white blood cell important to fighting off infections.

Exclusion - Trials - Participants - Access - Treatments

Exclusion from these clinical trials - which give participants access to the latest medical treatments - could prevent black men from receiving proper treatment.

The findings, published in JAMA Oncology, suggest researchers designing clinical trials set entry criteria that makes it harder for black patients to participate.

Exclusion - Criteria - Barrier - Patients - Part

'Something as simple as a lab-value exclusion criteria may serve as yet another barrier to allowing African American patients to take part in randomized trials,' said corresponding author Dr Paul Nguyen, of Brigham and Women's Hospital.

Prostate cancer is the second leading cause of death among men in the US, but doctors still aren't sure what causes the disease.

Risk - Factors - Disease - Age - Man

However, risk factors for the disease include age — the older a man is the greater his risk for developing the disease, family history, and face.

For the study, Dr Nguyen and his colleagues examined a list of 401 clinical trials regarding prostate cancer.

Half - Trials - Laboratory - Values - Race

They found out more than half of the clinical trials conducted used these laboratory values, which varied by race.

Many of the clinical trials measured serum creatinine (sCr), which is used to measure kidney function, and absolute neutrophil count (ANC), which is used to determine the health of a person's immune system.

Studies - Percent - People - Descent - Neutropenia

However, studies have shown that approximately 25 to 50 percent of people of African descent have benign ethnic neutropenia, a condition that lowers their ANC levels, but does...
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