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In the brain, dedicated groups of neurons that connect up in microcircuits help us process information about things we see, smell and taste. Knowing how many and what type of cells make up these microcircuits would give scientists a deeper understanding of how the brain computes complex information about the world around us. But existing techniques have failed to paint a complete picture.
The new technique, developed by researchers at the Francis Crick Institute, overcomes previous limitations and has enabled them to map out all 250 cells that make up a microcircuit in part of a mouse brain that processes smell -- something that has never been achieved before.
Method - Nature - Communications - Today - Scientists
The method, published in Nature Communications today, could be used by scientists worldwide to uncover the architecture of different parts of the brain.
"Traditionally, scientists have either used colour-tagged viruses or charged dyes with an applied electric current to stain brain cells, but these approaches either don't label all cells or they damage the surrounding tissue," said Andreas Schaefer, Group...
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