Glucose-induced nerve damage: Research identifies underlying mechanisms

ScienceDaily | 1/12/2018 | Staff
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The significance of the identification of a common molecular mechanism is that many more patients could potentially benefit from drugs that target this mechanism. In earlier research, Rieger identified two drug candidates for the treatment of chemotherapy-induced peripheral neuropathy that she is seeking to move into human clinical trials.

Peripheral neuropathy is a potentially disabling condition affecting up to 40 million Americans that causes, pain, tingling and numbness in the hands and feet. Treatments exist for alleviating pain, but the development of treatments to prevent or reverse nerve degeneration has been stalled by a lack of understanding of the underlying mechanisms.

Finding - Drug - Candidates - Neuropathy - Neuropathy

"This finding means that the drug candidates we have identified to treat chemotherapy-induced peripheral neuropathy could potentially be used to treat peripheral neuropathy that is caused by diabetes as well," Rieger said.

Diabetes affects an estimated 28 million people in the United States and over 300 million worldwide, 50 to 60 percent of whom suffer from peripheral neuropathy. That number is expected to double in the coming decades as a result of the fact that diabetes is approaching epidemic proportions worldwide.

People - United - States - Neuropathy - Cancer

About 450,000 people in the United States suffer from peripheral neuropathy caused by cancer chemotherapy, the second leading cause of the condition.

"Peripheral neuropathy is a major and growing health problem," said Kevin Strange, Ph.D., president of the MDI Biological Laboratory. "The identification of the mechanism underlying glucose-induced peripheral neuropathy means that millions of patients could potentially benefit from the development of drugs that influence this pathway."

Research - Zebrafish - Rieger - Compounds - Neuropathy

In previous research in zebrafish, Rieger identified two compounds that prevent and reverse peripheral neuropathy caused by exposure to Taxol, or paclitaxel, a common cancer chemotherapy agent. The compounds are the subject of a pending patent originally filed in 2016 by the MDI Biological Laboratory.

The recent study, published in theJournal of Diabetes and Its Complications, tested the...
(Excerpt) Read more at: ScienceDaily
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