An unusual form of antibiotic resistance in pandemic cholera

phys.org | 1/3/2018 | Staff
ziggy1023 (Posted by) Level 3
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Cholera is a devastating disease for millions worldwide, primarily in developing countries, and the dominant type of cholera today is naturally resistant to one type of antibiotic usually used as a treatment of last resort.

Researchers at the University of Georgia have now shown that the enzyme that makes the El Tor family of V. cholerae resistant to those antibiotics has a different mechanism of action from any comparable proteins observed in bacteria so far. Understanding that mechanism better equips researchers to overcome the challenge it presents in a world with increasing antibiotic resistance. The results of this research are published in the Dec. 22 issue of the Journal of Biological Chemistry.

Cationic - Peptides - CAMPs - Bacteria - Animals

Cationic antimicrobial peptides, or CAMPs, are naturally produced by bacteria and by animals' innate immune systems and are also synthesized for use as last-line drugs. Cholera strains achieve resistance to CAMPs by chemically disguising the bacterium's cell wall, preventing CAMPs from binding, disrupting the wall and killing the bacterium. M. Stephen Trent's research team in Georgia previously had shown that a group of three proteins carried out this modification and elucidated the functions of two of the proteins. The team reported the role of the third protein - the missing piece in understanding CAMP resistance - in the new paper.

Former graduate student Jeremy Henderson led a research project that showed that this enzyme, AlmG, attaches glycine, the smallest of the amino acids, to lipid A, one of the components of the outer membrane of...
(Excerpt) Read more at: phys.org
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