Restricting HIV-1 infection

phys.org | 9/4/2017 | Staff
aniki (Posted by) Level 3
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The HIV-1 capsid protein (CA) interacts with viral factors that support infection and host factors that restrict it. The host protein cyclophilin A (CypA) binds to CA and enhances the action of host restriction factors that block HIV-1 infection.

Christopher Aiken, Ph.D., and colleagues investigated how CypA potentiates the action of the restriction factor TRIM5alpha in African green monkey cells. They did not find evidence of a role for CypA in promoting binding of TRIM5alpha...
(Excerpt) Read more at: phys.org
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