Signaling by molecules called prostaglandins plays a key role in the body's response to inflammation. Prostaglandins been linked to the sensory perception of pain, but their role in the emotional response to pain is unclear. This week in the JCI, a study conducted by David Engblom's lab at Linköping University in Sweden has demonstrated that the aversive effects of inflammatory pain are driven by prostaglandin signaling specifically on serotonin-producing neurons in the brainstem.
When the researchers selectively blocked prostaglandin synthesis in neurons, mice displayed reduced aversive...
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