Predicting the degradation behavior of advanced medical devices

phys.org | 1/13/2020 | Staff
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Credit: Cell Reports Physical Science by Cell Press.

Polymer materials play a vital role in today's medicine. While many applications demand long-lasting devices, others benefit from materials that disintegrate once their job is done. The design of such materials largely depends on the capability to predict their degradation behavior.

Team - Researchers - Helmholtz-Zentrum - Geesthacht - Prof

A team of researchers at the Helmholtz-Zentrum Geesthacht led by Prof. Andreas Lendlein established a method to faster and more reliably predict the degradation of these polymer materials with sophisticated molecular architectures. The results have been reported today in the first issue of the journal Cell Reports Physical Science.

With the so-called Langmuir technique, the authors transfer the material into a 2-D system, and thereby circumvent the complex transport processes that influence the degradation of three-dimensional objects. They created analytical models describing different polymer architectures that are of particular interest for the design of multifunctional implants and determined the kinetic parameters that describe the degradation of these materials.

Step - Scientists - Data - Computer - Simulations

In the next step, the scientists want to use these data to carry out computer simulations of the decomposition of therapeutic polymer devices. Regulatory authorities already prescribe computer simulations of the performance of such devices, for example for some stents. The insights gained by the 2-D degradation studies are...
(Excerpt) Read more at: phys.org
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