New Ohio State University research shows an association between breast cancer survivors' use of proton pump inhibitors (PPIs) and reports of problems with concentration and memory. On average, cognitive problems reported by PPI users were between 20 and 29 percent more severe than issues reported by non-PPI users. PPIs are sold under such brand names as Nexium, Prevacid and Prilosec.
The study, the first to look at PPI use in breast cancer survivors, used data from three previous Ohio State clinical trials examining fatigue, a yoga intervention and vaccine response in breast cancer patients and survivors. In each of those studies, participants had reported their use of prescribed and over-the-counter medications and rated any cognitive symptoms they had as part of routine data collection.
Variety - Factors - Cognition - Depression - Illnesses
After controlling for a variety of factors that could affect cognition -- such as depression or other illnesses, types of cancer treatment, age and education -- the researchers found that PPI use predicted more severe concentration and memory symptoms as well as lower quality of life related to impaired cognition.
"The severity of the cognitive problems reported by PPI users in this study was comparable to what patients undergoing chemotherapy had reported in a large observational study," said Annelise Madison, lead author of the study and a graduate student in clinical psychology at Ohio State. "PPI non-users also reported problems, but were definitely getting better. Based on what we're seeing, we don't know if PPI users might not be able to fully recover cognitively after chemotherapy. It's an area for further investigation."
Study - Online - Journal - Cancer - Survivorship
The study is published online in the Journal of Cancer Survivorship.
Madison pursued this study based on her knowledge of PPIs' known potential to bypass the blood-brain barrier and previous research suggesting that off-label use of PPIs in cancer patients may increase tumors' responsiveness to chemotherapy and protect the...
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