Human exposure comes from ingestion, direct skin contact, or inhalation and can lead to a variety of symptoms ranging from gastroenteritis, nausea, allergic reactions and skin rashes to hepatic injury and hemorrhage in more severe cases. Microcystins also have been linked to tumor progression and are harmful to renal, immune and reproductive systems.
A researcher from Florida Atlantic University's Harbor Branch Oceanographic Institute collaborated with the United States Centers for Disease Control and Prevention to test a newly developed immunocapture protein phosphatase inhibition assay (IC-PPIA) method for detection of microcystins and nodularin in human urine. This method uses a commercially available antibody to specifically isolate microcystins and nodularine from human urine prior to measurement.
Results - Study - Journal - Toxins - Demonstrate
Results of the study, published in the journal Toxins, demonstrate that the IC-PPIA method developed by the CDC was able to detect low-dose human exposures to microcystins by analysis of urine from three of the 86 urine specimens analyzed by this new method, which yielded positive results with concentrations of 0.055, 0.089 and 0.052 ng/mL MC-LR equivalents. These findings are the first to report microcystin concentrations directly from exposed residents impacted by...
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