One of the things that control cell growth are proteins in the cell membrane. In this regard, EGF receptors ('EGF' stands for Epidermal Growth Factor) form a central interface between the cell and its environment. This is why disruption to this system is a frequent cause of cancers, which arise from incorrectly controlled cell growth.
Many drugs have a direct impact on EGF receptors. These drugs work by focusing on two key areas: The first is the sensory domain, which reaches out of the cell and interacts directly with messenger substances that bind to the cell externally. The second is the kinase domain, which is located inside of the cell and transmits the signal. In certain cancers, the cells have already developed a resistance to active ingredients that target these two domains.
EGF - Receptor - Domain - Juxtamembrane - JM
The EGF receptor additionally comprises one other domain: the juxtamembrane (JM) segment between the external sensory domain and the kinase domain. We know that molecules also interact with this segment and can influence the transmission of signals as a result. But so far we know very few interaction partners. It is also unclear exactly how these interactions take place.
Researchers from HHU and FZJ as well as the...
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