Cancer research: Molecular machinery critical for cell's ability to move identified

ScienceDaily | 12/19/2019 | Staff
The driving force for cell migration is produced by a protein called actin. Actin monomers act as building blocks by polymerising into rod-like filaments that push the leading edge of the cell forward. The polymerisation of the actin filaments must be balanced by depolymerisation of the filaments at the other end.

Now, scientists at the University of Helsinki, Finland, and Institut Jacques Monod, France, have identified a molecular machinery which drives rapid depolymerisation of actin filaments and recycles the resulting actin monomers for a new round of polymerisation. Two proteins, cyclase-associated protein and cofilin, work together in this.

Crystallography - Computer - Simulations - Details - Proteins

"By using X-ray crystallography and computer simulations, we could actually see the atomic details of how these two proteins embrace actin filaments and disassemble them into their...
(Excerpt) Read more at: ScienceDaily
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