Blue mushroom dye used to develop new fluorescent tool for cell biologists

phys.org | 8/26/2013 | Staff
penaertpenaert (Posted by) Level 3
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A new fluorescent tool for detecting reactive oxygen species based on a chemical found in mushrooms has been developed by scientists at the University of Bath.

Reactive oxygen species (ROS), such as free radicals and peroxides, are produced in cells under oxidative stress. Whilst present in healthy cells in small amounts, excessive ROS in cells are damaging and can lead to cancer and neurodegenerative diseases such as Alzheimer's Disease.

Scientists - Bath - Researchers - South - Korea

The scientists at Bath, collaborating with researchers in South Korea, have developed a new probe that biologists studying these diseases can use to see changes in cells under the microscope, helping them to understand the fundamental biological processes involving ROS.

They've created a family of new molecules—dubbed AzuFluor—based on azulene, a bright blue chemical found in the mushroom Lactarius indigo. It fluoresces when it comes into contact with a ROS in a one-way reaction, detecting tiny amounts of these reactive oxygen species.

Whilst - Probes - Photon - AzuFluor - Photons

Whilst most fluorescent probes absorb a single photon, AzuFluor absorbs two photons, meaning that two lower energy photons can be used to produce the same level...
(Excerpt) Read more at: phys.org
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