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The lack of a clinically viable method to track and direct cancer drugs to tumors is a big problem for targeted therapeutics.
But a new ultrasonic method proposed by biomedical engineers from Qifa Zhou's team at the University of Southern California in Los Angeles could enable acoustic control and real-time tracking of drug release within the body. The researchers report on their manipulation of ultrasonic waves to pinpoint drug delivery in Applied Physics Letters.
Drug - Delivery - Tissue - Vivo - Microscope
"In conventional drug delivery, tissue is examined ex vivo under the microscope, or radioactive materials are used to trace drugs in vivo. We propose a new way to image and move the drug precisely inside the human body by combining the new plane wave imaging method with a focused ultrasound transducer," said post-doctoral researcher Xuejun Qian.
Accurate drug delivery is crucial to ensure tumor obliteration, while avoiding the toxic side effects of cancer therapeutics on healthy tissue. Ultrasound is a popular method for noninvasively imaging inside the body. But because the conventional method lacks sensitivity, it has not been used in drug delivery previously. Zhou's team adapted a new, ultrafast ultrasound method that eliminates background noise to accurately track a drug delivery vehicle within a phantom blood vessel.
Hanmin - Peng - Scholar - University - Aeronautics
Hanmin Peng, a visiting scholar from Nanjing University of Aeronautics & Astronautics, China, and co-workers pumped water through a narrow silicone tube to mimic blood flow through a blood vessel. They placed the tube beneath real pig tissue and imaged across this to make the...
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