Tiny droplets open the doors to in-flight imaging of proteins

phys.org | 4/4/2019 | Staff
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For the first time, researchers have demonstrated the creation of a beam of nanodroplets capable of delivering a variety of biological samples, from cell organelles to single proteins, virtually free from any contaminations, to the focus of an X-ray laser which can be used to image them.

The experiment was performed at the Linac Coherent Light Source (LCLS) at the Department of Energy's SLAC National Accelerator Laboratory and reported in the latest issue of Science Advances.

Sample - Delivery - Instrument - Ionization - Technology

By designing a new sample delivery instrument which uses electrospray ionization technology scientists have been created droplets of around 100 nm in diameter, about 1000x smaller than with previous techniques.

Previous techniques created droplets millions of times bigger than the sample within it, which caused the accumulation of any contaminants, which inevitably exist in the solution, on top...
(Excerpt) Read more at: phys.org
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