Study confirms protein as potential cause of most common type of pancreatic cancer

ScienceDaily | 9/4/2019 | Staff
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"The USP family is the largest group of enzymes known as cysteine proteases, which play an important role in tumor development and cancer stem cell biology," said Ronald DePinho, M.D., professor of Cancer Biology. "Genomic analysis identified frequent amplification of USP21 in PDAC. This overexpression correlated with cancer progression in PDAC patient samples, drove malignant transformation of human pancreas cells, and promoted mouse tumor growth."

The researchers also found that depletion of USP21 impairs pancreatic tumor growth, achieved through USP21's ability to deubiquitinate and stabilize TCF7, a transcription factor that promotes cancer cell stemness. Protein ubiquitination is one of the most common post-translational modifications and can affect protein function in several ways, including protein stability...
(Excerpt) Read more at: ScienceDaily
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