How HIV infection may contribute to wide-ranging metabolic conditions

ScienceDaily | 7/25/2019 | Staff
camkizzle (Posted by) Level 3
HIV infects only a limited repertoire of cells expressing HIV receptors. But HIV infection is also associated with conditions involving the dysfunction of cells that cannot be infected by HIV, such as hardening of the arteries, dementia, kidney impairment, and certain heart problems. These HIV-associated conditions persist even after successful application of antiretroviral therapy, when no virus is found in the blood. Many of these conditions involve impairments in cholesterol metabolism. In the new study, Sviridov and colleagues examined the mechanisms that may contribute to HIV-associated metabolic conditions.

The results showed that the HIV protein Nef is released from infected cells in vesicles that are then rapidly...
(Excerpt) Read more at: ScienceDaily
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