E. coli superbug strains can persist in healthy women's guts

ScienceDaily | 7/23/2019 | Staff
Refel_4309 (Posted by) Level 3
This is of clinical concern because disease-causing E. coli bacteria can transfer from the digestive tract to the female urinary tract via the urethra, the urine duct, which is shorter and positioned differently in females than in males. The bacteria can then make their way into the bladder and other parts of the urinary tract.

More than a third of urine samples provided by those who had fluoroquinolone (Cipro) resistant gut E. coli tested positive for E. coli growth. Of those, nearly 77 percent were Cipro-resistant, and the clonal type of the bacteria matched the fecal sample.

E - Coli - ST131-H30R - ST1193 - Groups

Most of the pathogenic E. coli found belonged to the pandemic, multi-drug resistant ST131-H30R or ST1193 clonal groups that currently cause the majority of drug-resistant urinary tract and bloodstream infections. They were detected twice as frequently in the urine of people who had these specific strains in their gut, compared to other strains of E. coli in general.

In addition, the presence of ST ST131-H30R in the gut in this study was associated with older age.

Researchers - Participants - Prescription - Study - Type

The researchers also checked to see which participants might have had an antibiotic prescription during the study for any type of infection, including respiratory.

Three months after that earlier urine collection, urinary tract infections were diagnosed in nearly 7 percent of the 45 previously asymptomatic carries who consented to follow-up electronic medical record examination. The study participants were from the Puget Sound area.

Tract - Strains - E - Coli - Specimens

"The two pandemic fluoroquinolone-resistant urinary tract pathogenic strains of E. coli found in the clinical specimens are superior gut colonizers and tend to persist there," noted the researchers. "They can also show up, at an unusually high rate, in the urine of healthy women who did not have a documented urinary tract infection diagnosis at the time of sample testing. Both phenomena appear to be interconnected."

The researchers pointed out that...
(Excerpt) Read more at: ScienceDaily
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