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Alexey Moskalev, Ph.D., Head of the Laboratory of Geroprotective and Radioprotective technologies and co-authors from the Institute of biology of Komi Science Center of RAS, the Engelgard's Institute of molecular biology of RAS and Moscow Institute of Physics and Technology published an article titled "Transcriptome Analysis of Long-lived Drosophila melanogaster E(z) Mutants Sheds Light on the Molecular Mechanisms of Longevity" in Nature Scientific Reports.
The study sheds light on a genetic mutation found in a fruit flies that may result in longer lifespans. Using genome-wide transcriptome analysis, the team noted that lifespan extension and stress resistance in fruit flies—Drosophila—carrying the E(z) histone methyltransferase heterozygous mutation (E(z)), were correlated with changes in the expression levels of 239 genes. The expression levels of some of the genes were doubled in flies with the E(z) mutation.
Results - Study - Flies - Percent - Lifespan
According to the results of the study, the mutant flies had a 22 to 23 percent lifespan extension compared to the control group. In addition, these flies were more resistant to hyperthermia, oxidative stress and endoplasmic reticulum stress, which can disrupt processes designed to help cells stay healthy. The...
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