The work, which was predominantly funded following an award from the Medical Research Council, has been carried out by the LSTM's Centre for Drugs and Diagnostic (CDD). The results are published in the journal Nature Communications.
LSTM's Professor Giancarlo Biagini explained: "The antimalarial primaquine is a cornerstone of global efforts to eliminate malaria, for some 70 years it has been the only drug registered that has been demonstrated to be able to cure relapsing malaria and block transmission of the disease. However, little has previously been understood about the drug's mode of action, which is seriously undermining efforts to improve the safety and pharmacology profile of this important drug class."
Team - LSTM - Collaborators - Professor - Paul
The team at LSTM, working with key collaborators including Professor Paul O'Neill (University of Liverpool), Professor David Baker (London School of Hygiene and Tropical Medicine) and Professor Sangeeta Bhatia (Massachusetts Institute of Technology, USA) were able to replicate the interaction between the drug and the host enzymes...
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