Boosting the discovery of new drugs to treat spinal cord injuries using zebrafish

ScienceDaily | 7/19/2019 | Staff
Mijac (Posted by) Level 3
Spinal cord injuries can have devastating consequences because of their importance for day-to-day activities such as walking, but also because of the failure to regenerate, leading to permanent disabilities. These lesions are a complex clinical condition for which the current treatment options have limited success in neurological and functional recovery. "For a significant functional recovery, it is likely that different therapies for multiple targets will be needed, due to the complex nature of the spinal cord lesions" starts explaining Leonor Saúde, "with this work we have shown that, using zebrafish, we can accelerate the discovery of new therapeutic targets for spinal cord lesions."

"Here, we have designed a simple and efficient platform that allows testing a large number of molecules and selecting them based on their ability to accelerate the regeneration of the spinal cord in zebrafish. Our platform consists of a model of spinal cord transection in zebrafish larvae where we test different therapeutic protocols and evaluate its efficacy through larvae locomotor function over time," explains Diana...
(Excerpt) Read more at: ScienceDaily
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