Alzheimer's drugs 'fail because of a patient's DNA'

Mail Online | 7/18/2019 | Alexandra Thompson Senior Health Reporter For Mailonline
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Alzheimer's drugs may fail because of a patient's DNA, research suggests.

A study found a genetic mutation that three quarters of people carry may be why so many medications work in animals trials but are ineffective in humans.

Gene - CHRFAM7A - Codes - Receptor - Acetylcholine

The gene CHRFAM7A codes for a receptor for acetylcholine, which transmits impulses within the nervous system. Acetylcholine is involved in memory and has long been associated with Alzheimer's.

Three out of four established Alzheimer's drugs, and more in development, work to stimulate acetylcholine receptors.

CHRFAM7A - Animals - Alzheimer - Studies - People

CHRFAM7A is not typically carried by the animals used in Alzheimer's studies but is mutated in three out of four people.

These unlucky patients are 'less likely to benefit' from dementia medications and require 'personalised treatment', the US researchers said.

Research - University - Buffalo - UB - Dr

The research was carried out by the University at Buffalo (UB) and led by Dr Kinga Szigeti, director of the Alzheimer‘s disease and memory disorders center.

Dementia affects 850,000 people in the UK, of which 62 per cent have Alzheimer's, according to the Alzheimer's Society.

US - People - Condition - Alzheimer - Association

And in the US, 5.8million people live with the condition, which is set to rise to nearly 14million by 2050, Alzheimer's Association statistics show.

Alzheimer's is incurable, with treatments only being able to temporarily relieve symptoms.

Dozens - Drugs - Development - Billions - Dollars

Dozens of drugs are under development, with billions of dollars being invested.

However, when it comes to treating Alzheimer's, there are many more setbacks than successes.

Proteins - Disease - Prevent - Symptoms - Patients

This has been blamed on the wrong proteins being targeted, ambitiously trying to 'cure' the disease rather than prevent symptoms and patients simply being treated too late.

(Excerpt) Read more at: Mail Online
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