All hematopoietic cells that develop in the bone marrow must cross the blood vessel wall to enter the circulation system. Blood platelets are released by bigger vessel-penetrating protrusions of huge, largely immobile progenitor cells, named megakaryocytes. In this way mature megakaryocytes produce platelets and release them into the blood circulation to maintain constant platelet counts. In addition, they actively regulate hematopoietic stem cell accumulation in a positive as well as negative manner.
Imaging the entire bone marrow with subcellular resolution to understand how all the players act in concert is still challenging. The research groups of Prof. Katrin Heinze and Dr. David Stegner established a profound 3D image reconstruction and segmentation pipeline for different bone marrow components. These segmented objects, originally derived from Light Sheet Fluorescence Microscopy, then serve as templates for computational simulations of cell distributions and their migration behavior in the bone marrow.
Study - Scientists - Stem - Cells - Neutrophils
In this study, the scientists found that hematopoietic stem cells and neutrophils migration depends on the megakaryocyte size and distributions. Thus, these simulations suggest that megakaryocytes play an important role in cell migration even if not migrating themselves. Instead, the large megakaryocytes represent passive obstacles, and thus significantly influence migration of other cells such as...
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