New insight into microRNA function can give gene therapy a boost

ScienceDaily | 7/17/2019 | Staff
emilia (Posted by) Level 3
The scientists profiled the division of microRNAs in different parts of endothelial cells, discovering that a large share of microRNAs are enriched in cell nuclei. When the scientists exposed the cell culture to hypoxia, they noticed that changes in the concentrations of individual microRNAs mostly took place either in cytoplasm or in the cell nucleus. This profiling study is the first one of its kind, showing that microRNAs play a more central role in regulating the expression of genes in cells than previously thought. For instance, the scientists found that microRNA-210, a molecule previously strongly associated with hypoxia, is in fact especially abundant in the cell nucleus. This observation sheds light on previously unknown mechanisms that cells use to adapt to hypoxia.

MicroRNAs weaken the expression of their target genes by binding to the ends of their messenger RNAs in cytoplasm. This...
(Excerpt) Read more at: ScienceDaily
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