Cholesterol-lowering drugs under-prescribed for prevention of atherosclerotic cardiovascular disease

ScienceDaily | 7/15/2019 | Staff
Frost123 (Posted by) Level 3
It should be noted that numerous studies have documented the benefits of appropriate statin use in at-risk populations, demonstrating reduction in atherosclerotic disease and the prevention of adverse outcomes like heart attacks, strokes, and deaths.

"Despite the known benefits of statins, a significant treatment gap persists in patients with ASCVD or at high risk of developing ASCVD. We need to conduct additional research to better understand contemporary management of these patients," said lead investigator Guanmin Chen, PhD, MD, MPH, Medlior Health Outcomes Research Ltd; Department of Community Health Sciences and Libin Cardiovascular Institute of Alberta; and O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Investigators - Patterns - Therapy - Management - LDL-C

Investigators assessed current patterns of lipid-lowering therapy for the management of LDL-C among 281,665 patients identified with ASCVD, based on administrative health system data for 2011-2015 from the province of Alberta. A retrospective study was conducted by linking multiple health system databases to examine clinical characteristics, treatments, and LDL. The objectives of the study were to characterize the proportion of patients with ASCVD and a statin prescription; to describe the intensity level of statins prescribed; and to determine the proportion of statin users who achieved recommended levels of LDL-C.

LDL-C was assessed at the first measurement (index test) and second measurement (follow-up test) during the study period. LDL-C levels were evaluated based on the 2016 Canadian Cardiovascular Society guideline recommendations for achieving less than 2.0 mmol/L or a 50 percent reduction. Statin therapies were categorized as low-, moderate-, and high-intensity.

Individuals - ASCVD - Study - Period - Percent

Among the individuals identified with ASCVD during the study period, 78 percent had an index LDL-C test and 66 percent were prescribed lipid-lowering therapy. Most patients receiving any lipid-lowering therapy were on moderate-/high-intensity statins. Failure to achieve guideline-recommended levels of LDL-C was common among patients using moderate- or high-intensity statin therapy; and 40...
(Excerpt) Read more at: ScienceDaily
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