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Two drugs that are used for breast and lung cancer could be combined to overcome tumour resistance in several types of the disease, new research suggests.
A study found that breast-cancer medication palbociclib was boosted when combined with the lung-cancer treatment crizotinib.
Cancer - Cells - Laboratory - Mice - Range
When tested on both cancer cells in the laboratory and mice with a range of malignant tumours, the duo was significantly more effective than the individual drugs.
The combined treatment both blocked cell division and induced senescence, which occurs when a cell loses its 'power' to divide and grow.
Palbociclib - Treatment - Advances - Breast - Cancer
While palbociclib has been described as one of the biggest treatment advances for advanced breast cancer in the past two decades, some tumours develop resistance to it.
This is often driven by a protein that crizotinib targets, with the two drugs together helping to overcome cancer cell resistance.
Research - Institute - Cancer - Research - ICR
The research was carried out by The Institute of Cancer Research (ICR) in London and University College London's (UCL) Cancer Institute.
It was co-led by Professor Paul Workman, chief executive of the ICR and Dr Sibylle Mittnacht, professor of molecular cancer biology at UCL.
Professor - Mittnacht - 'Our - Evidence - Medicines
Professor Mittnacht said: 'Our evidence shows that existing medicines could be used to overcome resistance to treatment in a frequent form of breast cancer in women.
'In addition, use of a current breast cancer medicine together with these other medicines could be a new, promising route for the treatment of lung and several other cancers.'
Professor - Workman - 'Cancer - Ability - Drug
Professor Workman added: 'Cancer's ability to adapt, evolve and become drug resistant is the biggest challenge we face in creating more effective treatments for the disease.
'We have shown the potential of combining two precision medicines for breast and lung cancer together to create a two-pronged attack that strips cancer cells of their resistance.'
Breast - Cancer - Women - Point - Lives
Breast cancer affects one in eight women at some point in their lives in...
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