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Mitosis is the process by which the genetic information encoded on chromosomes is equally distributed to two daughter cells, a fundamental feature of all life on earth. Scientists led by Alexander Dammermann at the Max Perutz Labs, a joint venture of the University of Vienna and the Medical University of Vienna, now examine how centrioles contribute to this process. The findings, published in Developmental Cell, help to elucidate the function of these tiny cellular structures in mitosis.
Correct mitosis requires the formation of a filamentous spindle that ensures that chromosomes are separated to opposite ends of the cell. Similar to ropes pulling a heavy weight, the spindle needs an anchor point from where it can develop. This point is provided by centrioles that accumulate a protein meshwork called the pericentriolar material or PCM around them to form centrosomes, which serve as both the origin and attachment site for the filaments of the mitotic spindle.
Centrioles - Formation - Centrosome - Role - Growth
While it was known that centrioles are essential for the initial formation of the centrosome, their role in further mitotic growth and maintenance of the PCM throughout cell division was previously unclear. The scientists were able to answer these questions with the help of C....
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