The vaccine appears to offer protection from one of the most common and painful side effects of cell therapy and shows promise for patients with immune-compromising conditions.
Using a non-live form of the herpes zoster virus that causes shingles, the researchers tested vaccination among people whose immune systems are wiped out during hematopoietic stem cell transplantation (HSCT). HSCT patients are especially prone to bouts of shingles, which is caused by reactivation of the latent varicella-zoster virus that also causes chicken pox.
Results - Blisters - Rash - Side - Body
The outbreak results in red, painful, burning blisters and rash, typically on one side of the body and often occurs in older adults or people with weakened immune systems. In some cases, shingles causes excruciating and long-lasting neurologic pain.
"This trial is important because it demonstrates that the vaccine works in severely immunosuppressed patients," said oncologist Keith Sullivan, M.D., the James B. Wyngaarden Professor of Medicine at Duke. "That suggests it could also work with others whose immune...
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