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From bugs to plants to animals, for all living things to grow they must create more cells. To do so, each existing cell, whether in an embryo or an adult, receives cues to copy its chromosomes—large pieces of DNA that contain each cell's entire genetic code. In a carefully and elegantly controlled process, each cell then divides into two.
However, this process can also go awry. If chromosomes are not correctly distributed to the two "daughter" cells, the new cells may die or grow uncontrollably, a hallmark of cancer. In fact, up to 90 percent of solid tumors are marked by a condition known as aneuploidy, where cells contain an incorrect number of chromosomes.
Mis-segregation - Happens - Cancer - Mark - Burkard
"We don't really understand how chromosome mis-segregation happens in cancer," says Mark Burkard, a medical oncologist and researcher with the University of Wisconsin–Madison Carbone Cancer Center. "One of the big disappointments, and opportunities, is that we know all these other genes that are mutated in cancers, but no one has really found the smoking gun for how chromosome segregation goes wrong."
Burkard and two of his UW Carbone colleagues—Beth Weaver, associate professor of cell and regenerative biology, and Aussie Suzuki, assistant professor of oncology—are leading efforts to better understand chromosome segregation and its contributions to disease.
Mechanisms - Segregate - Cells - Mechanisms - Cancers
"It's really important to understand the basic mechanisms of how chromosomes segregate in normal cells, and then look at whether those mechanisms are different in cancers," Burkard says.
Last fall, the McArdle Laboratory for Cancer Research at UW–Madison hired Suzuki to research these fundamental mechanisms. His lab studies how molecular interactions at the centromeres, the central point of dividing chromosomes, lead to their eventual separation.
Anyone - School - Biology - Class - Cell
Anyone who has taken a high school biology class may remember learning about the cell cycle and mitosis, the process of cell division. During mitosis, identical chromosome copies are held together...
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