Blood pressure drug linked with increased risk of bowel condition

ScienceDaily | 7/3/2019 | Staff
marika (Posted by) Level 3
The new early-stage research finding comes from a team of scientists led by Imperial College London, who investigated the effectiveness and side effects of three common blood pressure medications: ACE-inhibitors, beta-blockers and calcium channel blockers.

High blood pressure affects one in ten adults across the globe, and increases the risk of heart attack and stroke. The most common treatments for high blood pressure are lifestyle changes and medications.

Medications - Millions - Side - Effects - Effectiveness

However, despite the three main medications being taken by millions, investigating their potential side effects (as well as studying their effectiveness for treating other diseases), can be difficult and often involves lengthy and expensive clinical trials.

To overcome this problem, the research team, led by Imperial's School of Public Health, used genetic analyses to study the effects of the drugs.

Versions - Genes - Effects - Drugs - Team

By investigating versions of genes that mimic the effects of these drugs, the team were able to study the drugs' effectiveness -- and their potential side effects.

First, the researchers, who published their work in the journal Circulation, identified the proteins targeted by the drugs, and which help lower blood pressure. Next, they analysed genetic data from around 750,000 people and identified the so-called genetic variants that code for these proteins.

Team - Researchers - LMU - Munich - Gene

The team, who included researchers from LMU Munich, then studied whether these gene variants -- which cause increased production of these proteins -- were linked to an increased or decreased risk of other diseases.

The good news was that, as expected, these so-called genetic variants (which coded for proteins involved...
(Excerpt) Read more at: ScienceDaily
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