Both hypertension and hypotension can have adverse consequences for the health and lead to cardiovascular diseases and syncope, respectively. Now, researchers from the University of Copenhagen and Rigshospitalet know a little more about the factors that help regulate the blood pressure. The new research results have been published in the scientific journal, Journal of Biological Chemistry.
In interdisciplinary collaboration between researchers at the University of Copenhagen and Rigshospitalet, PhD student Lasse Holst Hansen found a particular form of carbohydrate or sugar on a particular peptide hormone in humans. In addition, in tests with rats the research team found that the peptide hormone with that particular form of sugar affects the regulation of the blood pressure. They hope that in the long term, their results can be used to develop better medications for hypertension.
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'It may be a really good bet for a modern way to treat hypertension without side effects, such as syncope. It has long been known that this peptide hormone is extremely important for the blood pressure, but so far it has not been possible to use it in the treatment. This finding was only possible because we collaborated across disciplines and combined basic and clinical research,' says Professor Jens Peter Gøtze, Rigshospitalet, the Department of Clinical Biochemistry.
About one in five Danes has hypertension. This increases the risk of cardiovascular diseases, such as coronary thrombosis and heart failure....
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