The researchers found that fecal miRNA, small nucleic acid sequences, could be used as a tool to assess the healthiness of gut microbiota, the microorganisms living in our gastrointestinal tract, and provide early clues to intestinal inflammation in mice.
Studies have shown that some microbiotas can play a role in the development of intestinal inflammation. Since disruption of the symbiosis between the microbiota and the intestine is associated with various inflammatory diseases, such as IBD and metabolic syndrome, it is essential to identify new biomarkers of microbiota healthiness. The findings, published in the journal Theranostics, are some of the first to show connections between fecal miRNAs and gut microbiota. Earlier studies to find biomarkers for IBD or inflammation have mostly been done from tissue and blood.
MiRNA - **** - Inflammation - Level - Microbiota
"We found that miRNA from **** are indicative of inflammation level as well as microbiota function," said Dr. Emilie Viennois, first author of the study and assistant professor in the Institute for Biomedical Sciences. "It can indeed indicate if the microbiota is more prone to induce inflammation or is more...
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