Dundee lab solves HOIL-1 mystery

phys.org | 3/27/2019 | Staff
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The mysterious function of a key protein has been revealed following a breakthrough by University of Dundee scientists.

HOIL-1 is a component of the Linear Ubiquitin Assembly Complex (LUBAC) which lies at the heart of the mechanism that determines whether the cells of our body will survive or die. Now researchers working in the laboratory of Professor Sir Philip Cohen in the University's Medical Research Council Protein Phosphorylation Unit (MRC-PPU) have found that HOIL-1 operates in tandem with a second component of LUBAC to form ubiquitin chains.

Research - Proceedings - National - Academy - Sciences

The research, which has just been published in the journal Proceedings of the National Academy of Sciences (PNAS), has also revealed that the ubiquitin chains are joined to other proteins by an unusual mechanism.

Sir Philip said, "It's been known since its discovery that HOIL-1 looks like an E3 Ligase, but nobody knew what it actually did in cells. Now we know.

Thing - Chains - HOIL-1 - Ubiquitin - Component

"One thing it does is to start new ubiquitin chains. HOIL-1 puts the first ubiquitin on, while a second component of LUBAC, called HOIP, attaches additional...
(Excerpt) Read more at: phys.org
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