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Noroviruses are a leading cause of food-borne illness outbreaks, accounting for 58% of all outbreaks and cause 685 million cases worldwide each year. There is no effective therapeutic against them. Having knowledge of the intricate structure of the outer layer of noroviruses, the capsid, which allows the virus to attach to its human host, could help in vaccine development.
In vaccines, specific antibodies recognize the capsids and bind to them so they can no longer interact with human cells. "We need to understand what the norovirus capsid shapes actually look like, and the shape differences between different strains," said James Jung, a postdoctoral fellow in Dr. Leemor Joshua-Tor's lab at Cold Spring Harbor Laboratory (CSHL).
Jung - Joshua-Tor - Team - High-resolution - Structures
Jung and Joshua-Tor led a team to solve the high-resolution structures of four different strains of noroviruses using a cryo-electron microscope. This allowed them to see the intricate architecture of virus shells in high-definition. Their findings are published in the journal PNAS.
Jung gleaned new insights that could help in guiding the development of therapeutics to...
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