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St. Jude Children's Research Hospital scientists have evidence the influenza virus functions like Velcro to help common respiratory bacteria gain a foothold in the airways. The research appears today as an advance online publication in the journal Nature Microbiology.
Researchers report for the first time that flu sticks to the surface of common respiratory bacteria and could significantly enhance the ability of the bacteria to adhere to cells that line the airways. Mortality was higher in mice infected with the virus-bacteria complex compared to mice infected with bacteria alone or flu and bacteria that were not incubated together prior to infection.
Bacteria - Surface - Virus - Bacteria - Ability
"The bacteria seem to decorate their surface with flu virus, which enhances the bacteria's ability to adhere to respiratory tissue early in the infection," said corresponding author Jason Rosch, Ph.D., an associate member of the St. Jude Department of Infectious Diseases. "This appears to be another way bacteria and virus work synergistically early in the infection to promote disease.
"The results offer insight for designing more effective vaccines."
Interactions - Viruses - Bacteria
Mutually beneficial interactions among different viruses and bacteria in...
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