Cancer: Using 3D to test personalized treatments in five days

ScienceDaily | 5/21/2019 | Staff
ashb0101ashb0101 (Posted by) Level 3
Colorectal cancer is the third most common form of cancer diagnosed today and the fourth most deadly in the world: 1.4 million people are affected each year, with 700,000 fatalities. A range of treatments is available, including chemotherapy, but the high dosages cause numerous side effects and patients commonly develop resistance. These treatments are currently tested on 2D tumour cell cultures before being administered to patients. "But that doesn't correspond to reality," explains Patrycja Nowak-Sliwinska, a professor at the School of Pharmaceutical Sciences at the UNIGE's Faculty of Science. "Not only does a tumour develop in 3D, but it also contains other types of cells, such as fibroblasts (tissues) and endothelial cells (blood vessels)." As a result, the Geneva-based scientists have built a new platform that uses a patient's tumour cell lines to recreate the tumour in 3D. It also keeps it alive, so that the impact of the treatments can be analysed during the different stages of its development.

The team headed by professor Nowak-Sliwinska, in collaboration with groups led by Didier Colin (HUG) and Olivier Dormond (CHUV), selected six cell lines derived from six different patients. The cells were stabilised in a hollow, U-shaped culture plate so that they stayed agglomerated and floated in a cell culture medium optimised to feed the tumour. "The structure can then be organised by itself in 3D and continue its development," says professor Nowak-Sliwinska. "The three types of...
(Excerpt) Read more at: ScienceDaily
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