Structural and functional mechanisms of a new class of bacterial sigma/anti-sigma factors revealed

phys.org | 4/11/2018 | Staff
lhumara (Posted by) Level 3
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Transcription is the process of synthesizing messenger RNA by RNA polymerase based on the DNA sequence of a gene and is the initial step in gene expression. In bacteria, σ factor is a key component of RNA polymerase for promoter recognition and transcription initiation.

In recent years, a type of σ factor, SigI, and its co-transcribed anti-σ factor, RsgI, have been widely found in some Clostridia and Bacilli. They represent a new class of bacterial σ/anti-σ factors. Previous studies have shown that these SigI/RsgI factors are responsible for cellulosome regulation, while the structural and functional mechanisms of these factors are still unknown.

Prof - Feng - Yingang - Colleagues - Qingdao

Prof. Feng Yingang and his colleagues from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences recently revealed the structural and functional mechanism of the SigI/RsgI factors from C. thermocellum. The results have been published in Nucleic Acids Research.

Cellulosomes are multi-enzyme complexes secreted by some anaerobic Clostridia and are efficient lignocellulose-degrading processors with important applications in both lignocellulose bioconversion and biotechnology development.

Synthesis - Components - Substrates - Study - Regulation

The synthesis of cellulosomal components is regulated along with extracellular substrates. Thus, the study of the substrate-induced regulation mechanism is crucial for the engineering of cellulosomes aimed at high activity and their related applications.

To study the...
(Excerpt) Read more at: phys.org
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