Dermcidin may play role in the pathogenesis of skin disease hidradenitis suppurativa

ScienceDaily | 4/25/2019 | Staff
penaertpenaert (Posted by) Level 3
HS is a chronic, recurrent inflammatory disease of the apocrine sweat glands, which impacts 1%-4% of people and is most prevalent in young adults. There are several treatments to help alleviate symptoms, however there is no known cure for the disease.

"Until now, the molecular drivers of HS have been poorly understood," said Victoria Shanmugam, MD, associate professor of medicine at the GW School of Medicine and Health Sciences. "Traditional therapies have thus far been disappointing. However, TNF-α inhibitors like infliximab and adalimumab have shown efficacy."

Shanmugam - Team - Patterns - HS - Skin

Shanmugam's team analyzed transcriptome patterns in HS skin to identify transcripts and upstream regulators that are differentially expressed in HS, compared to normal skin. The study found that dermcidin had the greatest fold change...
(Excerpt) Read more at: ScienceDaily
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