The arrestin-GPCR connection

phys.org | 2/22/2017 | Staff
katz1234 (Posted by) Level 3
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G-protein coupled receptors (GPCRs) are the "inbox" of environmental messages in mammalian cells. Because of their central role in signaling pathways, mutations resulting in abnormal GPCR functions cause a wide variety of diseases. Therefore, GPCRs are the most intensively studied drug targets.

After activation, GPCRs need to be deactivated by enzymes called GPCR kinases and a family of proteins called arrestins. Intriguingly, while there are hundreds of GPCR subtypes, mammals have only four arrestins. One region where arrestin subtypes differ...
(Excerpt) Read more at: phys.org
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