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In a paper published in the Journal of Biological Chemistry, Dr. Özdemir has studied two protein families named Rho GTPases and IQGAPs, which are known to play an important role in cancer metastasis. These two "suspicious" protein families have been studied by many researchers over the years, but the interaction between them had not previously been fully understood.
It is important to understand how metastasis, the spreading of cancer from its primary site to other organs, takes place, since preventing metastasis means keeping cancer under control. This is why Dr. Özdemir chose to study these proteins, which are known to activate metastasis.
Amount - Calculation - Study - Simulation - Techniques
Requiring a large amount of probabilistic calculation, the study was only made possible through computational simulation techniques with the help of very powerful computers. The researchers built a simulation environment in which many such elements as the water density in the cell, the ions and the three-dimensional structure of the proteins were very precisely simulated. This made it possible to observe how exactly the two proteins interacted, the points at which they bound,...
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