Could this gene explain the male infertility crisis? Scientists find DNA errors that hamper sperm

Mail Online | 4/18/2019 | Mia De Graaf Health Editor For
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Scientists have found infertile male mice lack a crucial 'repair gene' - and they hope it could provide answers for drops in sperm counts and sperm quality being recorded across the world in humans.

The gene, XRCC1, is crucial for sperm development, to ensure a high sperm count, swift motility, normal shape, and solid concentration.

XRCC1 - Fertility

Previously, it wasn't clear how important XRCC1 was to male fertility.

But a new study by Chinese researchers found it was the one thing that determined sperm quality in a batch of male mice.

Experts - Warrants - Research - Humans - Data

Experts say the finding warrants research in humans as data show a concerning rise in male infertility.

It's unclear, however, what might cause a deficiency in XRCC1.

DNA - Damage - Spermatozoa - Fertility - Risk

'Even modest DNA damage in human spermatozoa can reduce fertility and increase the risk of disease in offspring,' said Aihua Gu, a researcher at State Key Laboratory at the Ministry of Education School of Public Health in China.

'Now that we know XRCC1 plays a crucial role in maintaining normal spermatogenesis in mice, further study should explore potential treatments that could reverse male infertility caused by XRCC1 deficiency.'

Concerns - Infertility - Headlines - Researchers - Israel

Concerns about male infertility hit headlines globally in 2017, when researchers in Israel and the US published shocking data that sperm counts among men living in Western countries had fallen by...
(Excerpt) Read more at: Mail Online
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