When a person has a stroke, the brain responds with inflammation, which expands the area of injury and leads to more disability. In the April 9 issue of Cell Reports, USC researchers describe a key gene involved with tamping down inflammation in the brain, as well as what happens when the injured brain gets an added boost of that gene.
The gene -- called TRIM9 -- is abundant in the youthful brain but grows scarce with age, just as people become more at risk from stroke. In a lab model of stroke, researchers found that older brains with low TRIM9 levels -- or engineered brains missing the TRIM9 gene entirely -- were prone to extensive swelling following stroke.
Scientists - Virus - Dose - Gene - TRIM9-deficient
But when the scientists used a harmless virus to carry a dose of the gene directly into TRIM9-deficient brains, the swelling decreased dramatically and recovery improved.
Jae Jung, lead author and chair of the Department of Molecular Microbiology and Immunology at...
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