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Salmonella bacteria flip an electric switch as they hitch a ride inside immune cells, causing the cells to migrate out of the gut toward other parts of the body, according to a new study publishing on April 9 in the open-access journal PLOS Biology by Yaohui Sun and Alex Mogilner of New York University and colleagues. The discovery reveals a new mechanism underlying the toxicity of this common food-borne pathogen.
Salmonella are among the commonest, and deadliest, causes of food poisoning, causing over 400,000 deaths every year. Many of those deaths result when the bacteria escape the gut inside immune cells called macrophages. Macrophages are drawn to bacteria in the gut by a variety of signals, most prominently chemicals released from the site of infection. Once there, they engulf the bacteria as a regular part of their infection-fighting job. However, rather than remaining there, bacteria-laden macrophages often leave the site and enter the bloodstream, disseminating the bacteria and greatly increasing the gravity of the infection.
Tissues - Gut - Fields - Outer - Surfaces
Tissues such as the gut often generate small electrical fields across their outer surfaces, and...
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