A light-based carrier system for CRISPR-Cas9 gene editing

phys.org | 3/27/2019 | Staff
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A team of researchers from Nanjing and Xiamen Universities in China has developed an alternative to using viruses to transport CRISPR-Cas9 gene editing tools into a desired cell—and it involves two types of light. In their paper published in the journal Science Advances, the group describes their new type of carrier and how well it worked with test mice.

CRISPR-Cas9 gene editing tools are a coming revolution in treating genetic conditions, and scientists continue to test their abilities in a variety of applications. One area of study has involved looking for a replacement carrier system—the current approach uses a virus to carry the gene editing tool into a particular cell. Early on, researchers knew that the virus approach was not viable because of possible responses from the immune system, or worse, the threat of initiating tumors. In this new effort, the team in China has come up with an entirely new way to deliver the gene editing tool using two kinds of light.

Carrier - System - Nanoparticles - Radiation - NIR

Their carrier system consists of nanoparticles that are sensitive to low-energy near-infrared radiation (NIR) and that emit...
(Excerpt) Read more at: phys.org
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