Traffic jam in the cell: How are proteins assigned to specific transporters?

ScienceDaily | 4/1/2019 | Staff
ali11 (Posted by) Level 3
About a third of all the proteins that are made in our cells start their lives in the endoplasmic reticulum, that serves as a general protein factory. However, most proteins are needed at other cellular locations and need to be transported there. To avoid a "traffic jam," cells have evolved transport vesicles that act as a public transportation system: Passengers -- the protein cargo -- need to present the correct ticket to board the right bus -- a specific type of vesicle -- and end up at the correct destination.

Scientists have known for decades that small vesicles that form on the surface of organelles package specific proteins and transport them to other areas of the cell or the cell surface. "Mutations in genes involved in vesicular transport often lead to disease. It is therefore crucial to understand which proteins are transported by which vesicles. Unfortunately transport vesicles have a short life span and are challenging to purify, so they are difficult to analyse," states Prof. Dr Felix Wieland, who headed up the research at the Heidelberg...
(Excerpt) Read more at: ScienceDaily
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