In general, there is no fundamental treatment method capable of curing diseases caused by gene abnormality because it is difficult to remove certain genetic mutations from all affected cells. Loricrin keratoderma (LK) is one such disease; caused by loricrin mutations, it is characterized by dry, thickened, scaly skin from birth. Only symptomatic treatments are available to alleviate the conditions, which cause difficulties in patients' daily lives. Thus far, doctors have not known how to treat the ailment.
In a study published in Life Science Alliance, the research team, including Toshifumi Nomura and Shotaro Suzuki of Hokkaido University, observed the patients' skin for an extended period. They discovered that LK patients had normal-looking skin areas dotted around their body. Tissue from those areas was examined for histology, and DNA extracted from both the epidermis and dermis were checked for loricrin mutations.
Study - Areas - Fact - Skin
The study found skin areas that looked normal were in fact skin that had returned to normal and that, surprisingly,...
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