Hepatitis B virus sheds light on ancient human population movements into Australia

EurekAlert! | 3/21/2019 | Staff
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Australian researchers have used current hepatitis B virus (HBV) genome sequences to deduce ancient human population movements into Australia, adding weight to the theory that the mainland Aboriginal population separated from other early humans at least 59 thousand years ago and possibly entered the country near the Tiwi Islands.

The discovery was made as an offshoot of the Characterising Hepatitis B in Indigenous Australians thRough Molecular epidemiology (CHARM) study, commenced in 2010 by the Menzies School of Health Research (Menzies). Chronic HBV infection is endemic in Australian Aboriginal and Torres Strait Islander people and is an important cause of morbidity and mortality due to liver disease and liver cancer.

Part - Patients - Hepatitis - B - Infections

As part of caring for patients with hepatitis B infections in the CHARM study, the research team collected HBV samples from people living in over 30 communities across the NT and found HBV isolated from Aboriginal Australians is a unique strain not found anywhere else in the world, known as HBV/C4.

In the same way that human genome sequences are used to trace ancient human migration, the researchers predicted they could use modern day viral genomes to infer the movement of the people that have carried these viruses over many generations.

Molecular - Biology - Evolution - Study - Cutting-edge

Published in Molecular Biology and Evolution, the study used cutting-edge evolutionary analyses of the HBV DNA sequences together with archaeological fossil and human genome data.

The researchers found that the precursor of the modern HBV/C4 virus entered Australia over 51 thousand years ago, and then separated into two groups; one centred in the northwest region, and a second in the central/eastern region of the NT. Strikingly, the two groups share a similar geographical distribution to the two main divisions of Aboriginal Australian languages spoken in Australia today.

Co-author - Paper - Royal - Melbourne - Hospital

Co-author on the paper, the Royal Melbourne Hospital's Dr Margaret Littlejohn, who holds an honorary position with the University...
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