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South Korean scientists are working to improve cancer treatments with 3D bioprinting.
Professor Sun Ha Paek, Chairman in the Department of Neurosurgery at Seoul National University Hospital (SNUH), and Professor Dong-Woo Cho of the Pohang University of Science and Technology (POSTECH) have 3D bioprinted glioblastoma-on-a-chip devices to understand the behavior of cancer cells.
Glioblastoma - Glioblastoma - Multiforme - GBM - Form
Glioblastoma, also known as glioblastoma multiforme (GBM), is an aggressive form of cancer found in the brain or spinal cord. In a study published in Nature Biomedical Engineering, the scientists detail how extracted GBM cells from cancer patients in an ex vivo model can emulate the characteristics of GBM human tumors. Professor Paek explained:
“[THIS] SYSTEM CONFIRMS THAT CELL-PRINTING TECHNOLOGY COULD BE USED TO FIND A CUSTOMIZED ANTICANCER COMBINATION FOR EACH PATIENT IN THE FUTURE TREATMENT OF BRAIN CANCER.”
GBM - Form - Brain - Cancer - %
GBM is the most common form of brain cancer, accounting for approximately 50% of all malignant primary brain tumors, and is considered to be highly refractory (resistant) to chemoradiotherapy, according to the research.
A team of bioengineers, led by Professor Paek and Professor Cho sought to combat the ineffectiveness of such treatments by observing the isolated cancer cells from patients who had improved and deteriorating symptoms through chemotherapy.
Bioink - GBM - Vascular - Cells - Ring
Bioink consisting of GBM and human vascular cells were printed sequentially to create a concentric ring structure on a chip which was also 3D printed from oxygen-permeable silicone. Using this chip the structural, biochemical and biophysical properties of the GBM tumors could be replicated.
Schematic illustration of the bioprinting and use of the patient-specific GBM-on-a-chip for the identification of an optimal drug combination for the...
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